Tissue plasminogen and cargo are single-chain glycoproteins, which are mainly synthesized, secreted and continuously released into the blood by vascular endothelial cells. They are widely present in various tissues of the body, and the liver is inactivated by tissue plasminogen activator. The main place. It has a high affinity for fibrin, then forms plasminogen with tyrosine plasminogen, degrades fibrin (original) and partial coagulation factors, and is a key substance in the fibrinolytic system. Lowering suggests a decrease in fibrinolytic activity. Found in prethrombotic state and thrombotic diseases, such as arterial thrombosis, deep vein thrombosis, ischemic stroke.