Type B hemolytic streptococcus produces streptokinase, which is antigenic and stimulates the body to produce anti-streptokinase (ASK) antibodies. Principle of the anti-streptokinase assay: EIA is a special reaction that combines the specificity of the antigen-antibody reaction with the efficient solubilization of the enzyme.

Basic Information

Specialist classification: Infectious disease examination and classification: blood examination

Applicable gender: whether men and women apply fasting: fasting

Tips: Hypercholesterolemia, multiple myeloma and macroglobulinemia patients may have false positives, further examination is needed. Normal value

Normal value: < 1:80.

Clinical significance

(1) ASK titer can be significantly increased during acute rheumatic fever or rheumatic heart rheumatism. It has been reported that the duration of serum ASK varies widely in the blood, ranging from 5 weeks to 4 years.

(2) ASK positive is evidence of the presence of streptococcal infection, therefore, other diseases associated with streptococcal infection such as acute nephritis, nodular polyarteritis, etc., ASK can also be a positive result.

(3) Patients with acute myocardial infarction treated with streptokinase thrombolysis may be positive for serum ASK. This antibody is resistant to re-infarction patients using re-stase.

Positive results may be diseases: rheumatic fever, acute rheumatic heat kidney damage, streptococcal pharyngitis, rheumatic heart disease considerations

Patients with hypercholesterolemia, multiple myeloma, and macroglobulinemia may have false positives; false positives may occur when patients are treated with large amounts of antibiotics or hormones in the early stages of onset.

Inspection process

1. Laboratory materials: blood

2. Principle of anti-streptokinase assay: EIA is a special reaction that combines the specificity of antigen-antibody reaction with the efficient dissolution of enzymes.

3. Reagents: serum.

4. Method of operation: Use the EIA method of operation.

Not suitable for the crowd

Those who do not have an indication for examination should not do this check.

Adverse reactions and risks

Generally no complications and harm.