Carcinoembryonic antigen (CEA) is an acidic glycoprotein with a human embryonic antigenic determinant with a molecular weight of 150-200 kD. The CEA-encoding gene is located on chromosome 19. CEA is a large family of cell surface glycoproteins and is part of the immunoglobulin gene superfamily. Fetal and adult digestive tract produce a small amount of CEA, normal CEA is secreted into the gastrointestinal tract, while cancer cells that lose polarity secrete CEA into the blood and lymph, so the CEA in the blood increases.

Basic Information

Specialist classification: Digestive examination classification: biochemical examination

Applicable gender: whether men and women apply fasting: fasting

Analysis results:

Below normal:
normal.

Normal value:
Gastric cancer carcinoembryonic antigen: 35.58-262.04μg/L
Gastric carcinoembryonic antigen: 0.11-0.39μg/L

Above normal:
Elevated in gastric cancer, atrophic gastritis with intestinal metaplasia and dysplasia.

negative:

Positive:

Tips: A lot of smoking, CEA can also be elevated during pregnancy. Normal value

Gastric juice 35.58 ~ 262.44 μg / L.

The stomach tissue is 0.11 to 0.39 μg/g.

Clinical significance

Elevation: gastric cancer, atrophic gastritis with intestinal metaplasia and dysplasia.

High results may be diseases: gastric cancer, carcinoid, atrophic gastritis precautions

1, a large number of cigarettes, CEA can also be elevated during pregnancy.

2, chest, ascites, gastric juice can be directly measured.

Inspection process

Gastric juice gastric tissue carcinoembryonic antigen principle:

Based on the principle of homogeneous competition inhibition, the serum, plasma, pleural effusion, ascites and other body fluids were directly measured by unsaturated (sequential saturation) method. CEA in samples (standard, blood and reference serum, etc.) are pre-reacted with a limited amount of antibody for a period of time. 125I-CEA was then added to compete for the remaining antibody binding sites. When the concentration of CEA in the sample is high, the remaining antibody binding sites are small, so that 125I-CEA bound to the antibody is less. The antigen-antibody conjugate was separated using a separating agent, and the radioactivity in the conjugate was determined. It was found that the binding amount of 125I-CEA was a function of the concentration of CEA in the sample. After plotting the data of the standard points into a function curve, you can find the CEA concentration value in the specimen.

Reagents:

1. Standard: There are 6 kinds of 7 bottles of 0, 5.0, 10, 20, 40, 80μg/L, of which 0μg/L two bottles. The lyophilized product was dissolved in 1.0 ml of distilled water at the time of use.

2, 125I-CEA: 1 bottle, lyophilized product, dissolved in 10ml distilled water when used.

3. Anti-CEA: 1 bottle, lyophilized product, dissolved in 10ml distilled water when used.

4. Separating agent: 1 bottle, 100ml. Shake well and use directly. All reagents were stored at 4 ° C after dissolution and were valid for 2 weeks. The reagent contained in the assay cartridge was measured for 100 tubes. Different batch numbers are not allowed to be used interchangeably.

Not suitable for the crowd

Patients with gastric perforation.

Adverse reactions and risks

Mucosal injury: Avoid excessive exertion when removing gastric juice from the gastric tube to avoid damage to the nasal cavity and esophageal mucosa.