Plasma fibrinogen is a precursor of fibrin, and in the final stage of coagulation, soluble fibrinogen is converted to insoluble fibrin, which causes blood to coagulate. Determination of plasma fibrinogen helps to understand the state of coagulation function. Acquired pregnancy-induced toxicosis, infectious diseases, malignant tumors, cerebral infarction, myocardial infarction, surgery, collagen disease, diabetes, nephrotic syndrome, fibrinogen-containing blood preparations for long-term or large-scale input (AHG anti-human globulin preparation, fresh Frozen plasma) and so on.

Basic Information

Specialist classification: growth and development check classification: biochemical examination

Applicable gender: whether men and women apply fasting: fasting

Analysis results:

Below normal:
Found in fibrinogenemia.

Normal value:
Fibrinogen (biuret colorimetric method): 2-4 g/L

Above normal:
Increased in the infection.



Tips: Take blood for 12 hours and take fresh blood for inspection. Normal value

The biuret colorimetric method is 2 to 4 g/L (200 to 400 mg/dl).

Rocket electrophoresis 2.2~3.6g/L.

The coagulation method is 1.95~3.80g/L.

Clinical significance

1, increase

(1) Physiological characteristics are seen in elderly people, late pregnancy, oral administration of estrogen preparations, and after exercise.

(2) acquired in pregnancy poisoning, infectious diseases, malignant tumors, cerebral infarction, myocardial infarction, surgery, collagen disease, diabetes, nephrotic syndrome, blood preparation containing fibrinogen, long-term or large-scale input (AHG anti-human ball Protein preparation, fresh frozen plasma), and the like.

2, reduce

(1) Physiological findings in newborns.

(2) Congenital findings in fibrinogenemia, low fibrinogenemia, and abnormal fibrinogenemia.

(3) Acquired in

1 generation disorders: chronic hepatitis, cirrhosis.

2 increased consumption: disseminated intravascular coagulation (DIC), thrombosis, major bleeding, the use of snake venom preparations.

3 fibrinolysis: shock (shock), surgery (primary fibrinolysis), DIC (secondary fibrinolysis).

Low results may be diseases: amniotic fluid embolism, disseminated intravascular coagulation, high myocardial infarction may be disease: cerebral infarction, chronic hepatitis, malignant tumors

1. Take blood for 12 hours and take fresh blood for examination.

2, oral contraceptives can increase fibrinogen.

3, women's menstrual period, pregnancy, fibrinogen can also rise.

4, fibrinogen suddenly increased, often indicating the possibility of tumor metastasis.

Inspection process

1. Take a blood sample tube with a 2ml scale, add 109mmol/L sodium citrate 0.2ml, then add about 2ml of venous blood to the mark and shake. The plasma was separated by centrifugation for 10 min.

2. Take 10 x 100mm small test tubes and add 0.2ml of plasma, then add 0.2ml of 36mmol/L calcium chloride solution or 0.2ml of thrombin, mix and set at 37°C for 1h.

3. Shake the small test tube to loosen the fibrin clot. Insert a small glass rod along the wall of the tube to gently press the fibrin clot, slowly release the fibrin, and finally roll the fibrin onto the small glass rod.

4. Wash the fibrin piece 4 times with water.

5. Take 2 tubes of 15×150mm and write the measuring tube (U) and the blank tube (B).

6. Put the fibrin into the U tube, add 0.2 ml of 2.5 mol/L sodium hydroxide to each of the U and B tubes, and then heat the U tube in a boiling water bath at 100 ° C for 5 min until the fibrin is completely dissolved.

7 and 2 tubes each add about 5 ml of water and 1.0 ml of phenol reagent, and then add water to 10 ml each, and finally add 3 ml of each of 1.9 mol/L sodium carbonate solution. After standing at room temperature for 30 min, the B tube was used as a blank tube, and the absorbance of the U tube was read at a wavelength of 580 to 640 nm, and the standard curve of the pre-painted standard was used to obtain the plasma fibrinogen concentration result.

Not suitable for the crowd

Hemophilia and diffuse intravascular coagulation.

Adverse reactions and risks

Discomfort: There may be pain, swelling, tenderness, and visible subcutaneous ecchymosis at the puncture site.