SHBG binds to testosterone and estrogen. Testosterone 40% binds to SHBG, 58% binds to albumin, and estrogen 75% combines with SHBG, 20% and albumin to form a complex that is mainly degraded in the liver. Sexhormone-bindingglobulin (SHBG), also known as testosterone-estradiol-binding globulin, SHBG is a carrier of transport hormones, which changes during the action of sex hormones and in various physiological and pathological conditions. significance. In conjugated testosterone, 44%-60% binds to SHBG; estrogen binds to specific SHBG in the blood circulation by about 95%.

Basic Information

Specialist classification: growth and development examination classification: blood examination

Applicable gender: whether men and women apply fasting: fasting

Tips: Anticonvulsant drugs, thyroxine (which directly promotes the liver's ability to synthesize) cause elevated serum levels; arginine hydroxyandrostenone, stanozolol, testosterone (inhibition of SHBG biosynthesis) can reduce serum levels. Normal value

1. Combined capacity method (SHBG-BC) (nmol/L).

Serum cord blood is 20.8-58.9.

1 month to 2 years old 52.0 to 218.6.

Prepubertal children 62.4 ~ 190.7.

Adolescent male 13.9 ~ 86.8.

Female 31.2 ~ 111.0.

Adult male 17.4 ~ 52.1.

Female 34.7 ~ 104.0.

All of the above are nmol/L combined with testosterone.

2. SHBG-BC ammonium sulfate precipitation method (nmol/L).

Serum adult male 41.5 ± 10.2.

Female 65.0 ± 24.1.

3. Immunoassay (nmol/L).

Serum adult male 10 to 80.

Non-pregnant women 20 to 130.

52 to 168 weeks of pregnancy 10 to 15 weeks.

20 to 25 weeks 170 to 260.

35 to 40 weeks 321 to 456.

Amniotic fluid 12 ± 4.0.

The nmol/L calculation is based on the binding of one molecule of steroid to each of the dimeric polypeptide chain molecules (MW is 59000).

Clinical significance

Hyperthyroidism, excessive use of estrogen and thyroid hormone, anorexia nervosa, cirrhosis and other patients with elevated serum levels; and hypothyroidism, excessive testosterone, hirsutism, obesity, polycystic edema ovarian syndrome, etc. reduce.

The result is low, the disease may be high : the hyperthyroidism result is high, the disease may be: hypothyroidism, hirsutism

Anticonvulsant drugs, thyroxine (which directly promotes the liver's ability to synthesize) cause elevated serum levels; arginine hydroxyandrostenone, stanozolol, testosterone (inhibition of SHBG biosynthesis) can reduce serum levels.

Inspection process

Reagent

Fresh serum should be used for analysis and cannot be measured in time. It can be stored for at least 8 months at -20 °C.

Method of operation

Commonly used immunoassay, combined with volumetric method and sulfuric acid precipitation method.

Not suitable for the crowd

no.

Adverse reactions and risks

no.