Both beta-platelet globulin and platelet factor 4 are derived from alpha particles of platelets and are platelet-specific proteins. The concentration of both in plasma depends on the amount of platelet synthesis and release, and is also related to renal excretion and clearance in the body. Radioimmunoassay: plasma 25.3 ± 3.0 μg / L, enzyme-linked immunosorbent assay: plasma 16.4 ± 9.8 μg / L.

Basic Information

Specialist classification: cardiovascular examination classification: biochemical examination

Applicable gender: whether men and women apply fasting: fasting

Analysis results:

Below normal:
Reduced in no megakaryocyte thrombocytopenia, autoimmune thrombocytopenia.

Normal value:
Plasma β-platelet globulin (radioimmunoassay): 21.3-28.3 μg/L
Plasma β-platelet globulin (茫?.6-26.2μg/L)

Above normal:
Increased in myeloproliferative diseases, thrombocytopenia, von Willebrand's disease, cerebral infarction, thrombotic thrombocytopenic purpura (no increase in primary thrombocytopenic purpura), DIC, deep vein thrombosis, diabetes, Epilepsy, migraine, oral contraceptives.

negative:

Positive:

Tips: oral dipyridamole, indomethacin, sulfinpyrazone, aspirin, etc., can inhibit the release of platelet factor 4, leading to a decrease in platelet factor 4 determination; application of heparin can determine platelet factor 4 results Raise. Normal value

Radioimmunoassay plasma 25.3 ± 3.0 μg / L;

Enzyme-linked immunosorbent assay plasma 16.4 ± 9.8 μg / L.

Clinical significance

1. Raise

Found in myeloproliferative diseases, thrombocytopenia, von Willebrand's disease, cerebral infarction, thrombotic thrombocytopenic purpura (no increase in primary thrombocytopenic purpura), DIC, deep vein thrombosis, diabetes, epilepsy, Migraine, oral contraceptives.

2, lower

Found in no megakaryocyte thrombocytopenia, autoimmune thrombocytopenia.

Low results may be diseases: high incidence of platelet weakness in children may be disease: thrombotic thrombocytopenic purpura, thrombocytopenia precautions

Oral dipyridamole, indomethacin, sulfinpyrazone, aspirin, etc., can inhibit the release of platelet factor 4, resulting in a decrease in the determination of platelet factor 4; the use of heparin can increase the platelet factor 4 measurement.

Inspection process

Blood was taken for measurement by the RIA method.

Not suitable for the crowd

no.

Adverse reactions and risks

1. Infection: Pay attention to aseptic operation when collecting blood, avoid contamination of water and other parts at the blood collection site to avoid local infection.

2, bleeding: after the blood is given a full compression time, especially coagulopathy, bleeding tendency, to avoid local subcutaneous oozing, bruising and swelling.