Plasma cyclic adenosine monophosphate is a small molecule haplo-cyclic adenosine nucleoside is a heat-resistant small molecule compound commonly found in biological cells and body fluids. It is produced by ATP in the presence of adenylate cyclase and Ca2+. . cAMP and cGMP work together to regulate cell growth and reproduction, and are closely related to various physiological and biochemical metabolic processes. It is the second messenger in cells.

Basic Information

Specialist classification: inspection classification: biochemical examination

Applicable gender: whether men and women apply fasting: fasting

Analysis results:

Below normal:
After intravenous administration of glucagon 10 μg/kg for 10 min, a decrease in urinary cAMP indicates hypoparathyroidism.

Normal value:
Plasma cyclic adenosine monophosphate (3H-labeling method): 17.4-30.6 nmol/L
Plasma cyclic adenosine monophosphate (125I-protection 6.4-31.8nmol/L)

Above normal:
After intravenous administration of glucagon 10 μg/kg for 10 min, plasma cAMP rises, indicating severe hepatitis, decompensated cirrhosis, etc. (the method for determining the severity of liver disease can be tried). A rise in cAMP in the urine indicates hyperparathyroidism. After intravenous administration of parathyroid hormone (PTH) for 20 minutes, cAMP in the urine increased, indicating idiopathic and postoperative hypoparathyroidism, pseudohypoparathyroidism type II.

negative:

Positive:

Tips: Before the examination, the diet is light and alcohol is prohibited. Check for an empty stomach in the morning. Normal value

17.4 to 30.6 nmol/L (3H-label method).

16.4 to 31.8 nmol/L (125I-label method).

Clinical significance

The increase and decrease of normal values ​​have no significant clinical significance, and various load tests must be performed to observe the dynamic changes of cAMP.

1. After intravenous administration of glucagon 10 μg/kg for 10 min, the plasma cAMP rises, indicating severe hepatitis, decompensated cirrhosis, etc. (the method for determining the severity of liver disease can be tried). A rise in cAMP in the urine indicates hyperparathyroidism, and a decrease in hypoparathyroidism.

2, intravenous administration of parathyroid hormone (PTH) 20min, urine cAMP increased, showing idiopathic and postoperative hypoparathyroidism, pseudohypoparathyroidism type II.

High results may be diseases: hypothyroidism precautions

If cAMP is too low, it means excessive energy consumption.

Inspection process

Blood was taken for measurement, and the assay was performed by the same 3H-labeling method and 125I-labeling method.

Not suitable for the crowd

no.

Adverse reactions and risks

no.