Serum type IV collagen

Collagen is a fibrillar glycoprotein, which is an alpha-peptide chain network formed by triple helix. Type IV collagen is an important component of the basement membrane. When liver disease develops with inflammation, fibrous tissue proliferates actively, and a large amount of collagen is deposited during the process of production, and various collagens are increased, but the most important one is the increase of type IV collagen constituting the basement membrane. It is currently believed that the determination of type IV collagen can be used as a modern indicator for examining liver fibrosis.

Basic Information

Specialist classification: Digestive examination classification: biochemical examination

Applicable gender: whether men and women apply fasting: fasting

Analysis results:

Below normal:

Normal value:
Serum type IV collagen: 0-140 ng/ml

Above normal:
In patients with chronic hepatitis, cirrhosis, and liver cancer, serum type IV collagen is significantly increased, and the degree of increase is based on primary liver cancer, liver cirrhosis, chronic active hepatitis, chronic prolonged hepatitis, and acute viral hepatitis.



Tips: Before the examination, the diet is light and alcohol is prohibited. Check for an empty stomach in the morning. Normal value


Clinical significance

Type IV collagen is an indicator mainly used for observing cirrhosis, and its concentration is related to the degree of liver fibrosis. The degree of cirrhosis can be estimated from the serum type IV collagen concentration.

1. In acute hepatitis, although there is a large amount of hepatocyte destruction, there is no significant difference in serum type IV collagen concentration and healthy people because there is no obvious connective tissue hyperplasia.

2, chronic hepatitis, cirrhosis, liver cancer patients, serum type IV collagen are significantly increased, the degree of increase is based on this is primary liver cancer, cirrhosis, chronic active hepatitis, chronic prolonged hepatitis, acute viral hepatitis.

High results may be diseases: liver fibrosis, liver cancer, liver cirrhosis, chronic hepatitis precautions

When the tissue and organs rich in vascular basement membrane components are lesions, abnormalities of type IV collagen and basal degradation fragments may also occur, such as hyperthyroidism, scleroderma, and advanced diabetes, which should be identified clinically.

Inspection process

Immediately after venous blood collection, the test was performed by competitive radioimmunoassay, and the solid phase second antibody was used as a separating agent to determine the C-IV content in serum, body fluids and tissues.

Not suitable for the crowd

Those without indications should not be tested.

Adverse reactions and risks

Risk of infection: If you use an unclean needle, you may be at risk of infection.