Serum 2 microglobulin (2-MG)

22 microglobulin is a beta light chain of human leukocyte antigen molecules. Its main function is to participate in the surface recognition of lymphocytes and is related to the killing of cells. Almost all nucleated cells in the body can synthesize β2 microglobulin and attach to the cell surface. The amount of β2 microglobulin produced daily by the same individual remains constant and is secreted in various body fluids. Determination of β2 microglobulin in blood, urine, and cerebrospinal fluid is important for the diagnosis of various diseases.

Basic Information

Specialist classification: examination classification: blood examination

Applicable gender: whether men and women apply fasting: fasting

Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. The alcohol content in the blood directly affects the test results. Fasting for 12 hours before taking blood, taking fresh blood for examination. Normal value

Plasma is 0.8 to 2.4 mg/L.

Serum 2.14 to 4.06 mg / L.

(Note that the detection method is different, the reference value will be different.)

Clinical significance

Abnormal result

Increased in:

1, renal dysfunction, seen in a variety of acute and chronic nephritis, renal failure, kidney tumors, renal transplant rejection.

2, malignant tumors such as primary liver cancer, lung cancer, stomach cancer, colorectal cancer, multiple myeloma, lymphocytic leukemia, malignant lymphoma.

3. Autoimmune diseases such as SLE (systemic lupus erythematosus), Sjogren's syndrome, rheumatoid arthritis, sarcoma-like disease, AIDS disease, autoimmune hemolytic anemia, etc.

4, tube graft rejection.

High results may be diseases: gastric cancer, autoimmune hemolytic anemia, multiple myeloma, primary liver cancer

Before inspection:

1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results.

2. Fasting for 12 hours before taking blood, taking fresh blood for inspection.

When checking:

When you draw blood, you should relax your mind, avoid the contraction of blood vessels caused by fear, and increase the difficulty of blood collection.

After inspection:

1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma.

2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended.

3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved.

4. If there is localized congestion, use a warm towel after 24 hours to promote absorption.

Inspection process

The blood of the subject is drawn and measured by immunological or chemiluminescence.

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Adverse reactions and risks