Serum leucine aminotranspeptidase is widely distributed in various tissues of the human body. It is most abundant in liver, pancreas, gallbladder, small intestine, uterus and muscle. It is also distributed in duodenum, serum and urine. Aminotranspeptidase has a certain significance in the evaluation of the diagnosis and treatment of hepatobiliary diseases.

Basic Information

Specialist classification: Digestive examination classification: biochemical examination

Applicable gender: whether men and women apply fasting: fasting

Analysis results:

Below normal:
Rare.

Normal value:
Male: 18.3-36.7U/L
Female: 16.3-29.2 U/L

Above normal:
Elevation can be seen in cholangiocarcinoma, pancreatic cancer, or gallstones and other causes of extrahepatic obstruction, drug-induced liver damage, viral hepatitis, intrahepatic bile stasis, acute hepatitis, malignant lymphoma, lymphosarcoma, pregnancy, no jaundice Liver metastases and the like.

negative:

Positive:

Tips: fasting for 12 hours before blood draw, take fresh blood for examination; pregnant women, long-term drinkers, serum leucine aminotranspeptidase can be elevated. Normal value

(1) Enzyme rate method (37 ° C)

Male 18.3 to 36.7 U / L.

Female 16.3 to 29.2 U/L.

(2) Color method

27 to 50 U/L.

(Note the specific reference value depends on each laboratory.)

Clinical significance

Elevation can be seen in cholangiocarcinoma, pancreatic cancer, or gallstones and other causes of extrahepatic obstruction, drug-induced liver damage, viral hepatitis, intrahepatic bile stasis, acute hepatitis, malignant lymphoma, lymphosarcoma, pregnancy, no jaundice Liver metastases and the like.

High results may be diseases: viral hepatitis, malignant lymphoma, cholangiocarcinoma

1. Fasting for 12 hours before taking blood, taking fresh blood for inspection;

2, pregnant women, long-term drinkers, serum leucine amino transpeptidase can be increased;

3, the results of the test, can be affected by certain drugs, such as gentamicin, tobramycin, polymyxin, sulfonamides.

Inspection process

Immediately after venous blood collection, the test was carried out by continuous monitoring method: 3.0 ml of pH7.2 phosphate buffer solution was added to a 1 cm diameter cuvette, and 0.1 ml of the substrate solution was added, and then pre-warmed to 30 ° C serum 0.1 ml, and mixed. Immediately enter the instrument and measure the absorbance continuously at 405 nm to find ΔA/min.

Not suitable for the crowd

no.

Adverse reactions and risks

no.