Magnesium is one of the most abundant cations in the body. Adults contain 0.823 to 1.234 mol of magnesium, 50% of which is present in bones, 45% in intracellular fluids, and 5% of extracellular fluids. Liver, kidney and muscle contain more magnesium. The content of magnesium in the cells is second only to potassium, and its concentration is about 10 times that of extracellular fluid. In the extracellular fluid, the content of magnesium ranks fourth only after sodium, potassium and calcium. Magnesium participates in the reaction and plays an important role in many physiological and chemical processes, such as activators of various enzymes. Alkaline and acid phosphatase, phosphomutase, pyrophosphatase, creatine kinase, hexokinase, leucine aminopeptidase and carboxylase, etc., their catalysis must be activated by magnesium ions, magnesium is also The elements necessary for the formation of DNA, RNA and ribosomal macromolecules are also important elements in maintaining normal nerve function and muscle.

Basic Information

Specialist classification: growth and development check classification: biochemical examination

Applicable gender: whether men and women apply fasting: fasting

Analysis results:

Below normal:
Reduce the cause of digestive tract diseases.

Normal value:
Serum magnesium (Mg2+, Mg): 0.8-1.0mmol/L

Above normal:
Increased kidney disease.

negative:

Positive:

Reminder: Reagents and sample dosages can be scaled according to the requirements of different instruments. Normal value

0.8 to 1.0 mmol/L.

Clinical significance

1, serum magnesium increased

(1) Kidney disease Anyone who affects glomerular filtration rate can increase serum magnesium retention. Such as chronic nephritis oliguria, uremia, acute or chronic renal failure.

(2) Endocrine diseases such as hypothyroidism (myxedema), hypoparathyroidism, Addison's disease, untreated diabetic coma (rapid decline after treatment).

(3) Improper treatment measures Anyone who is treated with magnesium preparations may cause poisoning.

(4) Other diseases include multiple myeloma, severe dehydration, arthritis, acute viral hepatitis, amebic liver abscess, oxalic acid poisoning, etc.

2, serum magnesium reduction

(1) Digestive tract loss Long-term fasting, malabsorption or long-term loss of gastrointestinal fluids. Such as chronic diarrhea, malabsorption syndrome, intestinal fistula or biliary fistula after surgery, long-term attraction of gastric juice, alcohol poisoning and severe vomiting.

(2) endocrine diseases hyperthyroidism, hyperparathyroidism, correction of diabetic acidosis, primary aldosteronism and long-term use of corticosteroid treatment, all increase urinary magnesium excretion.

(3) Treatment measures Improper treatment with diuretics such as salimer or chlorothiazide did not promptly replenish magnesium. Long-term intravenous infusion without magnesium rehydration.

(4) Other diseases Acute pancreatitis can form magnesium soap around the pancreas; advanced cirrhosis can be secondary to aldosteronism; plus ascites diuretic; hypoalbuminemia can reduce magnesium binding; acute myocardial infarction, acute alcoholism And neonatal hepatitis, after intestinal resection of the baby.

3, increased urinary magnesium excretion seen in various reasons of polyuria, including long-term use of diuretics, renal tubular acidosis, primary aldosteronism, hypercortisolism, advanced treatment of diabetes, hyperparathyroidism, cortex Hormone therapy and tumor bone metastasis.

4, the reduction of urinary magnesium excretion is seen in long-term fasting, anorexia, malabsorption, hypoparathyroidism, adrenal insufficiency, can also be reduced.

Precautions

Mix and set for 5 min, use a wavelength of 600 nm or red filter, light path 1.0 cm colorimetric, adjust the absorbance to 0 point with a blank tube, and read the absorbance of each tube.

Inspection process

1. The reagent and sample dosage can be changed proportionally according to the requirements of different instruments.

2. If the test result is outside the test range, the sample should be diluted and tested, the number of factors adjusted or the result multiplied by the dilution factor.

3. Accuracy of the results The instrument is calibrated and the temperature and time are controlled.

4. The doctor makes a clinical diagnosis based on clinical symptoms and other test results.

Not suitable for the crowd

A patient with hemophilia and severe clotting factor deficiency.

Adverse reactions and risks

Discomfort: There may be pain, swelling, tenderness, and visible subcutaneous ecchymosis at the puncture site.