Serum globulin is a mixture of various proteins, including immunoglobulin veneers and complements, a variety of glycoproteins, metal-binding proteins, various lipoproteins, and enzymes. The content of globulin is generally obtained by subtracting albumin from total protein.

Basic Information

Specialist classification: cardiovascular examination classification: biochemical examination

Applicable gender: whether men and women apply fasting: fasting

Tips: Long-term use of immunosuppressive agents or adrenocortical hormone treatment can reduce globulin synthesis. Normal value

Normal value

Glyoxylic acid colorimetric method: 20-30 g/L (2.0-3.0 g/dl).

Clinical significance

1, rise in seeing

1 infection causes increased immune response, chronic viral hepatitis, active tuberculosis, kala-azar, schistosomiasis, malaria, wasps, subacute bacterial endocarditis.

2 The immune function of the body in autoimmune diseases, systemic lupus erythematosus (SLE), scleroderma, rheumatic fever, rheumatoid arthritis, cirrhosis, etc.

3 multiple myeloma, lymphoma, leukemia, some malignant tumors.

4 nephrotic syndrome, allergic reactions, pneumonia, filariasis.

5 physiological serum water reduction, blood concentration.

2, lower seen in

1 synthesis reduced, adrenal hyperfunction, such as Cushing's syndrome, the use of adrenocortical hormone or other immunosuppressive agents.

2 congenital immune function defects, such as γ-globulin deficiency.

3 after radiotherapy or nitrogen mustard poisoning.

4 normal babies are born to 3 years old.

High results may be diseases: mental disorders associated with scleroderma, Cushing's syndrome precautions

1. After the child is born to 3 years old, the serum globulin is reduced, which is physiologically reduced.

2, long-term application of immunosuppressive agents or adrenocortical hormone treatment, can reduce globulin synthesis.

Inspection process

The detection operation is shown in the table:

Mix and let stand for 10 min at room temperature. At a wavelength of 630 nm, adjust the zero point with a blank tube and read the absorbance of each tube.

The specimen is turbid, and can be used as a blank tube (serum 0.02ml plus succinate buffer 4ml), and then the absorbance of the measuring tube is subtracted from the blank tube absorbance, and the total protein-albumin = globulin content is calculated.

Not suitable for the crowd

Special diseases: Patients with hematopoietic dysfunction, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood.

Adverse reactions and risks

Risk of infection: If you use an unclean needle, you may be at risk of infection.