Serum globulin (G, GL0)
Serum globulin is a mixture of various proteins, including immunoglobulin veneers and complements, a variety of glycoproteins, metal-binding proteins, various lipoproteins, and enzymes. The content of globulin is generally obtained by subtracting albumin from total protein.Basic Information
Specialist classification: cardiovascular examination classification: biochemical examination
Applicable gender: whether men and women apply fasting: fastingTips: Long-term use of immunosuppressive agents or adrenocortical hormone treatment can reduce globulin synthesis. Normal value
Glyoxylic acid colorimetric method: 20-30 g/L (2.0-3.0 g/dl).Clinical significance
1, rise in seeing
1 infection causes increased immune response, chronic viral hepatitis, active tuberculosis, kala-azar, schistosomiasis, malaria, wasps, subacute bacterial endocarditis.
2 The immune function of the body in autoimmune diseases, systemic lupus erythematosus (SLE), scleroderma, rheumatic fever, rheumatoid arthritis, cirrhosis, etc.
3 multiple myeloma, lymphoma, leukemia, some malignant tumors.
4 nephrotic syndrome, allergic reactions, pneumonia, filariasis.
5 physiological serum water reduction, blood concentration.
2, lower seen in
1 synthesis reduced, adrenal hyperfunction, such as Cushing's syndrome, the use of adrenocortical hormone or other immunosuppressive agents.
2 congenital immune function defects, such as γ-globulin deficiency.
3 after radiotherapy or nitrogen mustard poisoning.
4 normal babies are born to 3 years old.High results may be diseases: mental disorders associated with scleroderma, Cushing's syndrome precautions
1. After the child is born to 3 years old, the serum globulin is reduced, which is physiologically reduced.
2, long-term application of immunosuppressive agents or adrenocortical hormone treatment, can reduce globulin synthesis.Inspection process
The detection operation is shown in the table:
Mix and let stand for 10 min at room temperature. At a wavelength of 630 nm, adjust the zero point with a blank tube and read the absorbance of each tube.
The specimen is turbid, and can be used as a blank tube (serum 0.02ml plus succinate buffer 4ml), and then the absorbance of the measuring tube is subtracted from the blank tube absorbance, and the total protein-albumin = globulin content is calculated.Not suitable for the crowd
Special diseases: Patients with hematopoietic dysfunction, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood.
Risk of infection: If you use an unclean needle, you may be at risk of infection.