Serum angiotensin I converting enzyme activity

Angiotensin-converting enzyme is a binding glycoprotein containing zinc, which is a dipeptide carboxypeptidase. Angiotensin I can be formed into angiotensin II having a hematopoietic action, which causes further contraction of blood vessels and elevation of blood pressure. Angiotensin-converting enzymes can also inactivate bradykinin with antihypertensive effects, and may also act directly on the adrenal cortex to promote aldosterone secretion. It is an important regulator of the renin-aldosterone system and the bradykinin system. Determination of serum angiotensin I converting enzyme activity is commonly used in the diagnosis and active diagnosis of sarcoidosis.

Basic Information

Specialist classification: Respiratory examination classification: blood examination

Applicable gender: whether men and women apply fasting: fasting

Tips: Take venous blood to separate serum for testing. Hemolysis and chyluria do not affect the test results, but bilirubin (xanthine) has a significant inhibitory effect on ACE, and should be detected in time after blood collection. Normal value

Normal average (33.3 ± 10.2) U / ml.

Clinical significance

This test is applicable to the diagnosis of active sarcoidosis and the evaluation of the efficacy of sarcoidosis hormone therapy.

1. ACE elevation is more common in active sarcoidosis, the positive rate is between 75% and 88.2% (bronchoalveolar lavage fluid is more significant). The positive rate of active stage IV patients can reach 93.5%, and the increase rate is mostly about 2 times of the reference value of the control. When there is no active sarcoidosis or in hormone therapy, the ACE measurement value can be within the normal range. .

Also seen in silicosis, asbestosis, primary cirrhosis, acute miliary tuberculosis, hyperthyroidism, Hodgkin's disease, diabetes and so on.

2. After active hormone nodular disease, ACE is restored to normal, and continuous measurement in the process of using hormones is meaningful for reducing the dosage and stopping the hormone.

3. ACE reduction can be seen in Hodgkin's disease, acute or chronic leukemia, lung cancer and so on.

4. ACE has no correlation with blood pressure. However, serum ACE can be used as an indirect indicator of blood drug concentration monitoring when ACE inhibitors such as captopril are used to treat hypertension or congestive heart failure.

High results may be diseases: sarcoidosis, asbestosis, Hodgkin's disease considerations

1. Extract venous blood to separate serum for testing.

2. Hemolysis and chyle blood did not affect the test results, but bilirubin (Astragalus) significantly inhibited ACE.

3. During the inspection, ethyl acetate is absorbed at 228 nm, so be sure to evaporate completely when evaporated, and the evaporation temperature should not exceed 140 °C to prevent sublimation of hippuric acid. EDTA has a strong inhibitory effect and should not be mixed during operation.

Inspection process

Take an appropriate amount of blood and immediately send it for inspection.

Not suitable for the crowd

Inappropriate people: Generally there are no people who are not suitable.

Adverse reactions and risks

Symptoms of fainting such as dizziness, vertigo, fatigue, etc. after blood draw.