Acetacetic acid (AcAc) is one of the main components of the ketone body formed by incomplete oxidation of fat, accounting for 30% of the ketone body. Due to hunger, diabetes and other reasons, fat mobilization increases, the amount of synthetic ketone body in the liver exceeds the capacity of extrahepatic tissue utilization, ketone body accumulation in the body, causing ketoneemia and ketonuria, causing plasma pH to drop, leading to acidosis. There are chromogenic methods, enzymatic methods, gas chromatography, capillary isotachophoresis, etc., in which the enzymatic method is fast, simple, sensitive, and specific.

Basic Information

Specialist classification: inspection classification: biochemical examination

Applicable gender: whether men and women apply fasting: fasting

Tips: Hunger and mental stress can increase the concentration of acetoacetate. Normal value

<0.3 mmol/L (chemical method).

Clinical significance

After fatty acid metabolism, diabetes, hunger, acute alcohol poisoning, etc. will increase the content of acetoacetate. It can be used to identify and monitor the diagnosis and treatment of patients with diabetic ketotoxicosis.

High results may be diseases: alcoholism, diabetes, diabetic ketoacidosis precautions

Starvation and stress can increase the concentration of acetoacetate.

Inspection process

Immediately after venous blood collection, the test method is the same as the automatic biochemical analyzer.

Not suitable for the crowd

Inappropriate people: Generally there are no people who are not suitable.

Adverse reactions and risks

Discomfort: There may be pain, swelling, tenderness, and visible subcutaneous ecchymosis at the puncture site.