Thrombomodulin activity

Thrombomodulin is a single-chain glycoprotein. It is synthesized by megakaryocytes and endothelial cells and is widely distributed on the surface of vascular endothelial cells. It is a cofactor for thrombin-activated protein C. Determination of thrombomodulin activity has a certain significance for the diagnosis and treatment of certain diseases. Thrombomodulin (TM) binds to thrombin to reduce the clotting activity of thrombin and enhance the activity of its activated protein C. Since activated protein C has an anticoagulant effect, TM is an important intravascular coagulation inhibitor that turns thrombin from procoagulant to anticoagulation.

Basic Information

Specialist classification: cardiovascular examination classification: biochemical examination

Applicable gender: whether men and women apply fasting: fasting

Tips: Before the examination, the diet is light and alcohol is prohibited. Check for an empty stomach in the morning. Normal value

0.82 to 1.13 (chromogenic substrate method).

20 to 35 (radioimmunoassay).

Clinical significance

Increased in diabetes, disseminated intravascular coagulation, systemic lupus erythematosus, acute myocardial infarction, primary thrombocytopenic purpura, cerebral thrombosis.

High results may be diseases: diabetic ketoacidosis, disseminated intravascular coagulation, thrombocytopenic purpura, acute myocardial infarction, diabetes precautions

In patients with diabetic ketoacidosis, plasma TM is significantly increased. In addition to vascular endothelial injury, it may be associated with abnormal renal function, increased neutrophils and its release products affecting endothelial cells.

Inspection process

Immediately after blood collection, the test was carried out and the test method was determined by radioimmunoassay.

Not suitable for the crowd

Inappropriate people: Generally there are no people who are not suitable.

Adverse reactions and risks

1. Local subcutaneous hemorrhage: After the blood collection, the compression time should be sufficient, especially those with coagulopathy and bleeding tendency, so as to avoid subcutaneous oozing and bruising due to no blood coagulation.

2, infection: attention to aseptic operation during venous blood collection, so as not to cause local infection.