Platelet factor IV

Platelet factor 4 (platlet factor 4, PF4) is a specific protein synthesized from platelet alpha particles and is a tetramer of a polypeptide. It easily binds and neutralizes heparin and easily binds to heparan sulfate on the surface of vascular endothelial cells to slow down the inactivation of thrombin and promote thrombosis.

Basic Information

Specialist classification: cardiovascular examination classification: blood examination

Applicable gender: whether men and women apply fasting: fasting

Tips: Before the examination, the diet is light and alcohol is prohibited. Check for an empty stomach in the morning. Normal value

Plasma β-TG 25.3±3.0 μg/L, PF 43.2±0.8 μg/L.

Clinical significance

Increased plasma levels of β-TG and PF4 indicate that platelets are activated and their release response is hyperactive. Found in hypercoagulable state and/or thromboembolic diseases, such as acute myocardial infarction, cerebrovascular disease, uremia, pregnancy-induced hypertension syndrome, nephrotic syndrome, diabetic vasculopathy, disseminated intravascular coagulation, vascular sclerosis, Venous thrombosis. Therefore, β-TG measurement of ischemic heart and cerebrovascular disease prediction, the identification of diabetes with or without vascular disease, the importance of observing the prognosis of uremia.

High results may be diseases: acute myocardial infarction, disseminated intravascular coagulation, pregnancy-induced hypertension syndrome, uremia, nephrotic syndrome

If the blood collection technique does not meet the requirements, the measured value will be increased, and the glassware used should be siliconized.

Inspection process

Immediately after venous blood collection, the test was performed to avoid coagulation. The standard curve and the sample were measured by the equilibrium method. The sample was loaded according to the procedure in Table 1, and then thoroughly mixed on a vortex mixer for 15 minutes, centrifuged at 3000r/min for 25 minutes, and the supernatant was discarded to measure the standard tube and each sample tube sediment. The number of pulses.

Not suitable for the crowd

Inappropriate people: Generally there are no people who are not suitable.

Adverse reactions and risks

1, local subcutaneous hemorrhage: after the blood collection should be pressed for a sufficient time, especially those with bleeding tendency, so as not to cause subcutaneous oozing and bruising due to no blood coagulation.

2, infection: attention to aseptic operation during venous blood collection, so as not to cause local infection.