Isocitrate dehydrogenase

The determination of serum isotonic acid dehydrogenase has a certain significance in the diagnosis of liver disease, especially in patients with malignant tumors, and the increase in serum isotonic acid dehydrogenase is often a signal of liver metastasis. Reduced seen in large areas of hepatocyte necrosis.

Basic Information

Specialist classification: Digestive examination classification: biochemical examination

Applicable gender: whether men and women apply fasting: fasting

Tips: Common colorimetry. Normal value

1, colorimetric method 238 ~ 686U / L.

2. Enzyme rate method (37 ° C) 1 ~ 7U / L.

3, UV method 1.5 ~ 7.0U / L.

Clinical significance

1, elevated in acute hepatitis, chronic hepatitis, cirrhosis, liver cancer, liver metastases, cholelithiasis, cholecystitis, biliary obstruction, pancreatitis, right heart dysfunction, pulmonary infarction, neonatal jaundice, hemolytic disease.

2, reduced in large areas of liver cell necrosis.

High results may be diseases: cholelithiasis, cirrhosis, pancreatitis precautions

1. Factors that lead to increased ICD activity: hemolysis, Mn2+, Co2+, Mg2+, aminosalicylic acid, amphotericin B, androgen, anesthetic, carbon tetrachloride, chenodeoxycholic acid, chlorpromazine (cloprazine) ), ethanol, isoniazid, methotrexate, phenylbutazone (benzoxazolone).

2. Factors contributing to the decrease in ICD activity: ethylenediaminetetraacetic acid (EDTA), oxalate, sodium chloride, heavy metal ions, fluoride, β-chloromercuric benzoic acid, iodoacetate, Ba2+, Zn2+, CN- Wait.

Inspection process

Commonly used colorimetric method, enzyme rate method, ultraviolet method determination.

Not suitable for the crowd

Inappropriate people: Generally there are no people who are not suitable.

Adverse reactions and risks

Generally, this examination does not have too many adverse reactions and does not have much influence on the body.