The relationship between the ratio of apolipoprotein A1 (ApoA1)/apolipoprotein B (ApoB) and the severity of coronary artery stenosis. Coronary heart disease (CHD) is a common and frequently-occurring disease, and the morbidity and mortality are increasing year by year. Apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB) are two important indicators.

Basic Information

Specialist classification: cardiovascular examination classification: biochemical examination

Applicable gender: whether men and women apply fasting: fasting

Tips: Keep your mood steady and avoid irritability, excitement or sullenness. Normal value

1. The determination of APOAI can directly reflect the level of HDL-CHOL, accounting for 60% to 70% of the total HDL-CHOL protein. APOB is also synthesized by the liver, accounting for 97% of the total protein content of LDL-CHOL. The determination of APOB can directly reflect the level of LDL-CHOL.

2, APOA-I / APO-B ratio reduction <1 can be regarded as a risk indicator of cardiovascular disease.

Clinical significance

Abnormal result

Examination of atherosclerosis, mainly damage the inner wall membrane of the artery, involving the middle membrane is a pathological change in which the cholesteryl ester of the vascular wall accumulates into atherosclerotic plaque, which thickens and narrows the vascular wall fibers. Mainly invading the aorta and middle arteries, such as the aorta, coronary arteries and cerebral arteries, leading to insufficient local blood supply to certain organs, often cardiovascular and cerebrovascular diseases, and even fatal damage.

Low results may be diseases: cardiovascular disease, atherosclerosis considerations

Taboo before check-up: Keep your mood steady and avoid irritability, excitement or sullenness.

Requirements for inspection: follow the doctor's advice, use the medicine on time and in sufficient quantity.

Inspection process

1. Preparation before the examination: The subject should be fasted for 4 hours before the examination.

2. According to the doctor's request, cooperate with the doctor to extract serum.

3. Using the immunoturbidimetric method, the HDL1 content of the APOA1 is collected by the density gradient ultracentrifugation technique, and then the double-defatting method is used to remove the fat and the remaining heteroprotein, so that the electrophoresis-purified APOA1 antigen can be obtained. .

Not suitable for the crowd

People who need to be examined: cardiovascular and cerebrovascular diseases, nephrotic syndrome, active hepatitis, liver parenchymal damage, and diabetes patients need to be examined.

People with sudden symptoms and unchecked indications should not be tested.

Adverse reactions and risks

Generally, this examination does not have too many adverse reactions and does not have much influence on the body.