Synovial fluid examination is to check the synovial fluid in the joint to understand the condition of the joint synovium, which is helpful for the diagnosis of arthritis. For example, joint synovial fluid decreases with age, joint lacks lubricant, joints will have degenerative arthritis, bone spurs, osteoporosis, etc., and long-term lack of joint synovial fluid will also cause bone and joint necrosis. Normal value of synovial fluid examination: normal synovial fluid is a clear and transparent pale yellow liquid with no formation or crystallization. The number of cells is about 0.1X109/liter, which is mainly monocyte.

Basic Information

Specialist classification: growth and development check classification: body fluid examination

Applicable gender: whether men and women apply fasting: not fasting

Analysis results:

Below normal:
There may be damage to the body tissue leading to leakage of synovial fluid.

Normal value:
Normal synovial fluid: 0.3-2ml

Above normal:
Tips may have lesions in the joints.



Tips: Pregnant women are not suitable for this check. Normal value

Normal synovial fluid is a clear and transparent pale yellow liquid with no formation or crystallization. The number of cells is about 0.1X109/liter, which is dominated by monocytes.

Clinical significance

Abnormal results:

(1) Liquid volume: Normal synovial fluid is only 0.3 to 2 ml. The total amount of synovial fluid of various arthritis is different; in addition, from the increase or decrease of the amount of synovial fluid, it can be seen that the condition is improved or worsened.

(2) turbidity and color: turbidity of synovial fluid may be caused by more pus cells, such as infectious arthritis; may also be caused by crystallization or cellulose, such as gout and pseudogout; patients with rheumatoid arthritis The synovial fluid is grassy green, and the gout patient is white.

(3) Viscosity: normal synovial fluid is relatively thick, and when rheumatoid arthritis and infectious arthritis occur, synovial fluid becomes thin.

(4) White blood cell count and classification: According to the number of white blood cells obtained by examination, the degree of inflammation can be estimated to distinguish between arthritis, osteoarthritis, or infectious arthritis, rheumatoid arthritis, psoriatic arthritis, etc. . If the number of white blood cells that have risen gradually decreases, it means that the inflammation is getting better.

(5) Mucin clot: In a beaker containing 20 ml of 5% acetic acid solution, a few drops of synovial fluid were added, and after 1 minute, a clot was formed. This test can initially distinguish between inflammatory and non-inflammatory synovial fluids. For example, normal people, osteoarthritis, and arthritis patients have strong clots that are not easily broken, but patients with rheumatoid arthritis and infectious arthritis. The clot is easily broken.

(6) Chemical examination of synovial fluid: data on protein, glucose, antinuclear antibody, rheumatoid factor, complement, immunoglobulin, immune complex, etc. can be obtained by synovial fluid examination. In particular, the rheumatoid factor in synovial fluid appears earlier than the rheumatoid factor in the blood, and the positive rate can be higher than that in the blood.

(7) Crystallization examination: Examination of crystals on the smear by polarized light microscopy is helpful for differential diagnosis of gout and pseudogout.

(8) Bacterial examination: When joint infection is suspected, bacteria can be examined by smear staining. If necessary, it can be used for bacterial culture.

People who need to be examined: people with abnormal pain in the joints.

High results may be diseases: degenerative joint disease, synovitis, knee degenerative disease, joint degeneration, reactive arthritis after intestinal infection, bone hyperplasia

Taboo before inspection: no special contraindications.

Requirements for inspection: Check your relaxation and follow the doctor's instructions.

Inspection process

The patient or the control group was taken for puncture at the joint site. The rats were washed 5 times with normal saline 2 times, and the synovial fluid was taken. Immediately, the laboratory was examined under closed conditions.

Not suitable for the crowd

Taboo people: pregnant women.

Adverse reactions and risks