C-reactive protein (CRP) is a classical acute phase protein with a molecular weight of 104160u (105000) Daltons. It is a subunit of five structurally identical unglycosylated polypeptide subunits. It consists of 187 amino acids. It is a circularly symmetric pentahedron under electron microscope. It is insoluble in water and crystallized in rhombohedron. It may be precipitated by sodium sulfate. It is not heat-resistant (66C30min is destroyed) and its electrophoretic mobility is normal in β and N proteins.

Basic Information

Specialist classification: growth and development check classification: immunological examination

Applicable gender: whether men and women apply fasting: not fasting

Tips: High doses of aspirin reduce the CRP concentration in patients with CHD. Avoid taking this drug before doing the test. Normal value

Adults and children 0.068~8.2mg/L, median 0.58mg/L;

Neonatal or cord blood ≤0.6mg/L;

Infants ≤1.6mg/L from day 4 to month 1 after birth;

Women ≤ 47 mg / L during childbirth.

Clinical significance

1. Differential diagnosis of bacterial and viral infections:

Elevated GRP is positively correlated with the degree of infection. When the virus is infected, the serum concentration of CRP in most viral infections does not change much or remains essentially unchanged.

2. CRP and cardiovascular disease:

CRP is reported to be elevated during acute ischemia and myocardial infarction. CRP can predict the onset of ischemia in patients with unstable angina, the infarction of patients with angina pectoris, and the death of coronary artery in smokers. Even CRP can be used as a precursor to future myocardial infarction (MI) or stroke in healthy people.

3. CRP and gynecological diseases:

CRP measurement also contributes to the study of concurrent infection in gynecological patients. For pregnant women with amnion rupture and chorioamnion, CRP measurement has the most accurate and early predictive effect.


1. High doses of aspirin reduce CRP concentration in patients with CHD.

2. The concentration of CRP is positively correlated with the degree of coronary artery stenosis.

Inspection process

Complement binding assay.

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Adverse reactions and risks

There are no related complications and hazards.