EAC rosette formation test

The surface of B cells has membrane immunoglobulin, Fc receptor, complement receptor, mouse erythrocyte receptor and Epstein-Barr virus receptor. If human B cells bind to mouse red blood cells, a flower knot can be formed. The label of the B cell is estimated based on the formed flower knot, and in the case of a certain pathology, the rate of formation of the knot is increased. The EAC rosette formation test is helpful for the diagnosis and treatment of immunodeficiency diseases and lymphoproliferative diseases.

Basic Information

Specialist classification: Oncology examination classification: immune examination

Applicable gender: whether men and women apply fasting: not fasting

Tips: Actively cooperate with the doctor during the examination. Normal value

0.10 to 0.15.

Clinical significance

Reduced in the absence of gamma globulinemia, combined immune function defects.

Elevation is seen in chronic lymphocytic leukemia, hairy cell leukemia, congenital thymic dysplasia, and early stage of infectious mononucleosis.


Selective IgG, IgM, IgA deficiency, lymphoma, nephrotic syndrome, myeloma, radiation sickness, and the use of the immunosuppressant EAC-RFC can be reduced.

Inspection process

Same as T lymphocyte counting method.

Not suitable for the crowd

There are no taboos.

Adverse reactions and risks

There are no related complications and hazards.