Kveim test

The Kveim test is mainly used for the auxiliary diagnosis of nodular erythema, tuberous sclerosis, pruritus, nodular panniculitis, tuberous sclerosis, and nodular polyarteritis.

Basic Information

Specialist classification: growth and development check classification: immunological examination

Applicable gender: whether men and women apply fasting: not fasting

Tips: Check the changes in blood calcium and urine calcium levels before the test. Normal value


Clinical significance

Abnormal result

Red spots and induration appear, and gradually become apparent.

People who need to be examined are suspected of having active sarcoidosis:

After 10 days, purple-red papules appeared at the injection site, and after 4-6 weeks, they spread to 3-8 mm, forming a granuloma, which was a positive reaction. The skin with positive reaction was removed for tissue diagnosis, and the positive rate was about 75%-85%. There is a 2%-5% false positive reaction. This test can be turned negative as the disease is relieved. Helps to confirm active sarcoidosis, and 75% of patients with active sarcoidosis test positive.


Patients must first enhance treatment confidence and patience. Most of the disease can be treated or naturally relieved, but the recovery process often takes several years. Care should be taken to protect the eyes, skin, and joints from damage in the area; prevention of respiratory infections can reduce lung damage. Thoracic sarcoidosis: eye, nervous system, skin, heart muscle; pituitary lesions; myopathy; blood calcium, urinary calcium continued to increase.

SACE levels increased significantly; Note: contraindications - blood calcium, increased urinary calcium (vitamin D).

Contraindications before the test: banned drugs that cause changes in the levels of calcium and urine calcium in the blood.

Requirements for inspection: Actively cooperate with the doctor.

Inspection process

A 1:10 physiological saline suspension liquid was prepared as an antigen in lymph nodes or spleen tissues of patients with acute nodules. 0.1-0.2 ml of the suspension was taken for intradermal injection, and 10 days later, skin changes at the injection site were observed. Because of the lack of standard antigens, the application of this inspection is limited and has been gradually eliminated in recent years.

Not suitable for the crowd

Inappropriate people: people with severe allergies.

Adverse reactions and risks

There are no related complications and hazards.