Anti-PM-1 antibody is an anti-nuclear antibody, also known as anti-PM-Sol antibody, in patients with polymyositis, dermatomyositis or patients with systemic sclerosis/polymyositis (PSS/PM) overlap syndrome. . Gelpi et al. (1990) used 35S methionine-labeled Hela cell antigen and anti-PM-1 antibody-positive patient serum for immunoprecipitation, confirming that the antigen precipitated by anti-PM-1 antibody is a complex of 11-16 proteins with a molecular weight of 22kD. ~110kD, no nucleic acid. The PM-1 antigen is located in the nucleoplasm and nucleolus, and its function is not known, but it is believed that the role of antigen in the nucleolus may be more important.

Basic Information

Specialist classification: growth and development check classification: immunological examination

Applicable gender: whether men and women apply fasting: not fasting

Analysis results:

Below normal:

Normal value:
no

Above normal:

negative:
Healthy humans were negative for anti-PM-1 (anti-PM-1/Scl) antibodies.

Positive:
Positive suggestive of polymyositis/dermatomyositis (PM/DM), progressive systemic sclerosis (PSS), severely leading to PM/DM/PSS overlap syndrome.

Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. Normal value

Healthy humans were negative for anti-PM-1 (anti-PM-1/Scl) antibodies.

Clinical significance

Abnormal results were positive, leading to polymyositis/dermatomyositis (PM/DM), progressive systemic sclerosis (PSS), and severe PM/DM/PSS overlap syndrome.

Patients who need to be examined for lesions in the tendon and kidneys, or patients with the above symptoms.

Precautions

Before the test: Do not eat too greasy, high-protein food the day before the blood draw, avoid heavy drinking. The alcohol content in the blood directly affects the test results. After 8 pm on the day before the medical examination, fasting should be done to avoid affecting the detection of indicators such as blood glucose in the second sky.

When checking: When you take blood, you should relax your mind, avoid the contraction of blood vessels caused by fear, and increase the difficulty of blood collection.

Inspection process

After taking the blood, hand it to the doctor for examination. Actively cooperate with doctors.

Not suitable for the crowd

Not suitable for people: people with very low platelets or hemophilia patients.

Adverse reactions and risks

There are no related complications and hazards.