The nuclear RNP antigen antibody system is the second antigen-antibody system characterized by systemic autoimmune diseases. This system is nuclear RNP because it is located in the nucleus and the antigenicity of this system can be destroyed by nucleases and proteolytic enzymes. Recent molecular studies have shown that nuclear RNP belongs to a large family of snRNPs, and autoantibodies with this specificity can react with U1RNP particle components, one of the subfamilies of snRNPs. U1RNP particles contain A, C and 70 kD proteins, and autoantibodies react with antigenic determinants on A, C and 70 kD proteins.

Basic Information

Specialist classification: growth and development check classification: immunological examination

Applicable gender: whether men and women apply fasting: not fasting

Tips: Try to eat less and eat as much as possible, and arrange your diet reasonably. Normal value


Clinical significance

Antinuclear RNP antibodies are found in nearly 32% of SLE patients, and this autoantibody is found in almost all MCTD patients. In SLE, the anti-nuclear RNP autoantibody is only a large antigen and one antibody in the antibody profile, while in the MCTD, the nuclear RNP (U1RNP) antigen antibody system is predominant.


High titers and anti-U1RNP (especially high titer anti-70 kD) antibodies are considered diagnostic markers for MCTD.

Inspection process

Immunoblotting (WB) and indirect immunofluorescence (IIF).

Not suitable for the crowd

There are no taboos.

Adverse reactions and risks

There are no related complications and hazards.