Anti-gluten antibody (IgA-GA) is an autoantibody produced in patients with glucan enteropathy and belongs to IgA. Gluten contains gliadin, also known as prolamin, which is the main cause of gliadinal bowel disease. This substance cannot be absorbed by patients, and it is a causative agent and stimulates antibodies to produce anti-gluten antibodies.

Basic Information

Specialist classification: Digestive examination classification: immune examination

Applicable gender: whether men and women apply fasting: not fasting

Tips: Each laboratory should establish its own normal control value according to its own conditions. Normal value

still uncertain.

Clinical significance

Anti-gluten antibodies can be detected in the blood of patients with gliadinal enteropathy. Compared with anti-endothelium autoantibodies (IgA-EmA), the sensitivity of anti-gluten antibody detection is significantly improved (100%), but the specificity is The lower is only about 60%. In addition, the titer of the anti-gluten antibody varies with the presence or removal of gluten in the diet, and the rate of change is much faster than that of the anti-endometrial autoantibodies.

Patients with chronic liver disease often have anti-endothelium autoantibodies and/or anti-gluten antibodies. Patients with autoimmune hepatitis can be complicated by celiac disease and are often missed because of a lack of typical clinical manifestations. The positive rate of serum anti-gluten antibody in patients with chronic liver disease is significantly higher than that in the general population. The positive rates of serum anti-gluten antibodies were 20% for alcoholic liver disease, 19% for chronic hepatitis, and 11% for hepatitis C virus infection, which were significantly higher than normal. The mechanism and potential significance need further study.

Precautions

Each laboratory should establish its own normal control values ​​according to its own conditions.

Inspection process

Same as ELISA.

Not suitable for the crowd

There are no taboos.

Adverse reactions and risks

There are no related complications and hazards.