An antibody raised against thyroglobulin. ATG's target antigen thyroglobulin (TG) is a soluble iodinated glycoprotein synthesized and secreted by thyroid epithelial cells, with a molecular weight of 660 kD and consisting of 2748 amino acids. It is a biosynthetic precursor of T3 (triiodothyronine, triiodothyronine), T4 (tet-raiodothyronine, tetrathymidine, thyroxine, thyroxine), which is mainly stored in colloidal form in thyroid filtration. In the vesicle, the content of normal human serum is extremely small (10-40 ng/ml). Witebsky et al. immunized rabbits with the same thyroid tissue to induce thyroiditis in rabbits similar to ATG and Hashimoto's thyroiditis. ATG is the most typical organ-specific antibody among various autoantibodies in humans.

Basic Information

Specialist classification: growth and development check classification: immunological examination

Applicable gender: whether men and women apply fasting: not fasting

Analysis results:

Below normal:

Normal value:
no

Above normal:

negative:
normal.

Positive:
Positive in chronic lymphocytic thyroiditis, hyperthyroidism, primary hypothyroidism, certain liver diseases, various collagen diseases, myasthenia gravis, and some normal women.

Tips: Eat a reasonable diet and pay attention to rest. Normal value

negative.

Clinical significance

Positive in chronic lymphocytic thyroiditis, hyperthyroidism, primary hypothyroidism, certain liver diseases, various collagen diseases, myasthenia gravis, and some normal women.

Precautions

It has also been reported that 2% to 5% of normal people (mostly women) can detect ATG.

Inspection process

Indirect immunofluorescence.

Not suitable for the crowd

There are no taboos.

Adverse reactions and risks

There are no related complications and hazards.