Systemic lupus erythematosus is an autoimmune disease involving multiple organ systems. The main immunological feature is immunoregulatory disorder. In addition to the increased activation of T lymphocytes, B lymphocytes are activated by polyclonal, which produces a variety of autoantibodies in patients. One of them is made an anti-endothelial cell antibody (AECA). AECA binds to vascular endothelial cells (EC) and destroys EC through complement-mediated or antibody-dependent cytotoxicity, resulting in vascular damage, allowing patients to develop a range of clinical symptoms associated with them.

Basic Information

Specialist classification: growth and development check classification: immunological examination

Applicable gender: whether men and women apply fasting: not fasting

Analysis results:

Below normal:

Normal value:
no

Above normal:

negative:
normal.

Positive:
Prompt active lupus nephritis.

Tips: Serum, stored at -80 ° C for testing. Normal value

negative.

Clinical significance

Anti-endothelial cell antibodies are not associated with most clinical symptoms in patients with systemic lupus erythematosus. They are significantly associated with vasculitis and lupus nephritis, and are more common in the active stage of lupus nephritis. Therefore, anti-endothelial cell antibodies can be regarded as a marker of active lupus nephritis. one.

Precautions

Serum, stored at -80 ° C for testing.

Inspection process

Same as ELISA.

Not suitable for the crowd

There are no taboos.

Adverse reactions and risks

There are no related complications and hazards.