The molecular weight of heat shock protein-60 (HSP-60) is 60kD. Under the fever, inflammatory mediators and other forms of physiological stimulation, the level of HSP-60 in cells is elevated. HSP-60 is considered to protect cells under stress. From injury, HSP-60 has a protective effect on myocardial ischemic injury. The mechanism by which the HSP-60 autoantibody is produced may be: 1 viral infection integrates the HSP-60 polypeptide into an immature virus, and these polypeptides are immunogenic in vivo. 2 HSP-60 structural changes or post-translational modifications after viral infection, HSP-60 itself is immunogenic.

Basic Information

Specialist classification: growth and development check classification: immunological examination

Applicable gender: whether men and women apply fasting: not fasting

Analysis results:

Below normal:

Normal value:
no

Above normal:

negative:
normal.

Positive:
Prompt dilated cardiomyopathy.

Tips: HSP-60 antibody can be found in early type I diabetes, dilated cardiomyopathy, ischemic heart disease, etc., indicating that the above diseases are immune damage. Normal value

negative.

Clinical significance

Serum anti-HSP-60 antibody in patients with dilated cardiomyopathy is about 85%, and ischemic heart disease is about 42%. The difference between the two is significant, indicating that the onset of dilated cardiomyopathy is related to immune injury.

Precautions

HSP-60 antibodies may occur in early type I diabetes, dilated cardiomyopathy, and ischemic heart disease, indicating that the above diseases are immune damage.

Inspection process

Same as Western-blot method.

Not suitable for the crowd

There are no taboos.

Adverse reactions and risks

There are no related complications and hazards.