Anti-adrenal cortex antibody
Anti-adrenal cortex antibody (ACA) was originally discovered by Anderson et al., and its target antigen may be a glycoprotein in the adrenocortical cell microsome, which is a heterogeneous component. This antibody is mainly IgG. In the detection method, the complement application test and the indirect hemagglutination method were used earlier. The antigens used were all adrenal cortex homogenate supernatants, but they were still mainly detected by indirect immunofluorescence. In the hyperglycemia patients, the resected adrenal gland cryosection, the specific fluorescence in the adrenal gland, the myeloid junction is the brightest, localized to the cortical cytoplasm, most of the positive results showed the entire adrenal cortex infection, generally with 1:10 serum to be tested Sieves were then assayed for antibody titers of positive sera.Basic Information
Specialist classification: growth and development check classification: immunological examination
Applicable gender: whether men and women apply fasting: not fastingAnalysis results:
Early signs of adrenal failure.
Normal human serum anti-adrenal antibody titer <1:100 (indirect immunofluorescence).Clinical significance
In patients with autoimmune Addison disease, 60% to 70% of anti-adrenal antibodies are positive, while those of Addison who are caused by other causes are rarely positive. Antibodies can be positive in the years before adrenal insufficiency, indicating adrenal gland. Detection of cortical antibodies contributes to the early diagnosis of the disease. Anti-adrenal antibodies can also occur in patients with other autoimmune endocrine gland diseases. Adrenal cortical antibody-positive individuals in serum are not necessarily accompanied by adrenal insufficiency, but some patients may have adrenal insufficiency after a period of time. Adrenal cortical antibodies often occur simultaneously with anti-steroidal cellular antibodies, so patients with primary Addison disease often have gonadal failure. More than 90% of patients with autoimmune polyglandular syndrome type I have anti-adrenal antibodies, and 80% have anti-steroidal antibodies.
If adrenal cortical antibodies are detected in "normal humans", they can serve as early signs of adrenal failure.Precautions
First, the precautions before blood draw:
1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results.
2. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results.
3, should relax when taking blood, to avoid the contraction of blood vessels caused by fear, increase the difficulty of blood collection.
Second, after blood draw should pay attention to:
1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma.
2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended.
3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved.
4. If there is localized congestion, use a warm towel after 24 hours to promote absorption.
3. Please inform the doctor about the recent medication and special physiological changes before the test.Inspection process
Same as indirect immunofluorescence.Not suitable for the crowd
There are no taboos.Adverse reactions and risks
There are no related complications and hazards.