Refers to an antibody against the mitochondrial inner membrane lipoprotein component, without organ and species specificity. This antibody is mainly IgG. Commonly used rat stomach or kidney cortex as antigen matrix for immunofluorescence assay. AMA can be detected in many liver diseases. The positive rate was 90.5% in asymptomatic patients with primary biliary cirrhosis, 92.5% in symptomatic patients, and more than 90% in chronic active hepatitis; however, common bile duct obstruction and extrahepatic bile duct obstruction were negative. In addition, the positive rate of chronic active hepatitis and portal cirrhosis was 25%.

Basic Information

Specialist classification: examination classification: blood examination

Applicable gender: whether men and women apply fasting: not fasting

Analysis results:

Below normal:

Normal value:
no

Above normal:

negative:
normal.

Positive:
Found in primary biliary cirrhosis, chronic active hepatitis, autoimmune diseases (such as systemic lupus erythematosus, rheumatoid arthritis, etc.).

Tips: Because the patient needs to take some blood, the patient needs to undergo an empty stomach examination. Normal value

Indirect immunofluorescence is less than 1:10 (negative).

Clinical significance

Positive in primary biliary cirrhosis, chronic active hepatitis, autoimmune diseases (such as systemic lupus erythematosus, rheumatoid arthritis, etc.).

Positive results may be diseases: rheumatoid arthritis, hepatitis, biliary cirrhosis precautions

Contraindications before the examination: Because the patient needs to take some blood, the patient needs to undergo an empty stomach examination.

Requirements for examination: AMA is often used as an auxiliary diagnosis for the cause of jaundice and liver disease. It can be used as a basis for differential diagnosis of primary biliary cirrhosis and extrahepatic biliary obstructive cirrhosis. The doctor should pay attention to his diagnosis according to the examination process.

Inspection process

Laboratory Description: Anti-mitochondrial antibody (AMA) is an autoantibody that occurs primarily in the serum of patients with primary or biliary cirrhosis.

Inspection method: indirect fluorescent antibody method.

Not suitable for the crowd

Not suitable for the crowd: generally no special population.

Adverse reactions and risks

There are no related complications.