Trypsin is a hydrolase secreted by the pancreas. It can hydrolyze amino acid compounds linked by peptide chains and has esterase activity. The amount in normal serum is very small. Determination of serum trypsin has a certain significance in the diagnosis of acute pancreatitis. It not only acts as a digestive enzyme, but also inhibits the decomposition of precursors of other enzymes such as chymotrypsin, carboxypeptidase, and phospholipase, and activates it. It is the most specific protease and it is an indispensable tool in determining the amino acid arrangement of proteins.

Basic Information

Specialist classification: Digestive examination classification: feces / parasitic examination

Applicable gender: whether men and women apply fasting: not fasting

Analysis results:

Below normal:
Lowering suggests pancreatic exocrine insufficiency (late stage of chronic pancreatitis).

Normal value:
Duodenal juice: 150-600μg/ml

Above normal:
Elevation is seen in most patients with acute pancreatitis and chronic renal failure.

negative:

Positive:

Tips: Serum trypsin can rise to 2 to 400 times of normal people in acute pancreatitis, and usually returns to normal in 10 to 15 days. Normal value

(1) The RIA method is negative.

(2) Enzyme rate method (37 ° C), duodenal juice 150 ~ 600 μg / ml.

Clinical significance

(1) Increased trypsin in patients with acute pancreatitis and chronic renal failure, and increased pancreatic protease in more than half of patients with pancreatic cancer and chronic pancreatitis. However, there are also 20% of patients with non-pancreatic abdominal pain, especially those with perforation of cholecystitis and duodenal ulcer, and trypsin is also increased.

(2) reduce pancreatic exocrine insufficiency (late stage of chronic pancreatitis).

High results may be diseases: pancreatic true cysts precautions

In acute pancreatitis, serum trypsin can rise to 2 to 400 times of normal people, and usually returns to normal within 10 to 15 days.

Inspection process

Determined by enzyme rate method.

Not suitable for the crowd

No taboos.

Adverse reactions and risks

This test itself does not cause complications and harm.