Cerebrospinal fluid-bound myelin basic protein antibody
MBP is synthesized in oligodendrocytes. It consists of 170 amino acid residues with a molecular weight of 18,000 and is rich in lipids. The protein content is about 30%, and MBP is a component of nerve tissue. After nerve tissue damage, CSF is released within a few days. Therefore, the increase in MBP concentration in CSF can reflect the destruction of neuromyelin integrity.Basic Information
Specialist classification: examination classification: cerebrospinal fluid examination
Applicable gender: whether men and women apply fasting: fastingAnalysis results:
CSF-bound myelin basic protein antibody: 0-1.45μg/L
Found in multiple sclerosis, optic neuromyelitis, sporadic encephalitis, tuberculous spinal arachnoiditis, brain tumors, spinal cord tumors, hydrocephalus, cranial surgery, infectious polyradiculitis, subacute combined degeneration, brain Thrombosis, cerebral hemorrhage, pre-senile dementia, etc.
0.46 ± 0.96 μg / L.Clinical significance
Multiple sclerosis, optic neuromyelitis, sporadic encephalitis, tuberculous spinal arachnoiditis, brain tumor, spinal cord tumor, hydrocephalus, cranial surgery, infectious polyradiculitis, subacute combined degeneration, cerebral thrombosis The amount of antibodies in CSF, such as cerebral hemorrhage and pre-senile dementia, is elevated.
The worsening type of multiple sclerosis is mainly caused by the increase of FMBP and FMBPA, and the ratio of FMBP/BMBP is increased; the stable type is dominated by the increase of BMBP and BMBPA, and the ratio of FMBP/BMBP is decreased.High results may be diseases: multiple sclerosis, optic neuromyelitis, hydrocephalus
ELISA is a multi-reaction, multi-reagent, multi-step test method, which must be carefully and carefully operated according to requirements, otherwise accurate results will not be obtained.Inspection process
An ELISA procedure was used.Not suitable for the crowd
1. If there is obvious papilledema or cerebral palsy, contraindications are contraindicated.
2. Patients who are in shock, exhaustion or endangered state and local skin inflammation, and lesions in the posterior cranial fossa are contraindicated.Adverse reactions and risks
If the patient has symptoms such as breathing, pulse, or abnormal color during puncture, stop the operation immediately and deal with it accordingly.