Vulvar squamous cell hyperplasia


Introduction to vulvar squamous cell proliferation

Squamous epithelial cell hyperplasia is a vulvar disease in which genital itching is the main symptom but the cause is unknown. It used to be called proliferative malnutrition. In addition, genital itching of unknown cause, after long-term grasping and rubbing, can also lead to the proliferation of squamous epithelial cells, which is also known as chronic simple moss or neuropathy. Although other diseases such as Candida vaginal vulvitis can cause changes in the squamous epithelial cells in the vulva, but because of its clear cause, it can be cured quickly after treatment for its primary disease, so it is not in the scope of this disease. .

basic knowledge

The proportion of sickness: 0.01%-0.018%

Susceptible people: women

Mode of infection: non-infectious



Vulvar squamous cell proliferation


At present, the exact cause of vulvar squamous cell proliferation is still unclear. It is generally believed that factors such as long-term moisturization of the vulva skin and stimulation of vaginal discharge may be related to its pathogenesis. In addition, it has been reported that bcl-2 gene protein is increased in different degrees in this disease, dysplasia and vulvar cancer tissues.


The main histopathological changes were hyperkeratosis or parakeratosis of the epidermis. The spinous cell layer was irregularly thickened, the epithelial foot extended downward, the end was obtuse or sharp, and the longer the epithelial foot, the finer the tip. The dermal layer between the epithelial feet is obvious, with mild edema and lymphocytes and a small amount of plasma cells infiltrating. However, the epithelial cells were arranged neatly, the polarity was maintained, and the cell size and nuclear morphology were normal.


Vulvar squamous cell proliferation prevention

1. Develop good hygiene and keep the vulva clean.

2, when the vaginal secretions are abnormal, active treatment, to avoid further development of the disease and cause other diseases.

3, eat more coarse grains, add vitamins, enhance the body's immunity.


Vulvar squamous cell hyperplasia complications Complication

No relevant information.


Vulvar squamous cell hyperplasia symptoms common symptoms vulvar itching vulvar squamous epithelial hyperplasia vulvar injury vulvar swelling


The main symptom is genital itching, which is much more severe than sclerosing moss, and it is difficult for patients to endure. Due to the stimulation of large nerve fibers in the local area, nerve fiber reflex can be inhibited, and the patient's itching can be temporarily relieved. However, scratching can increase the skin lesions, making itching more dramatic. The result is more itchy, more itchy and more scratching, forming a vicious circle.


The lesions mainly involve the labia majora, interlabial space, clitoris foreskin and posterior labia. The lesion can be isolated, focal or multiple, symmetrical. In the early stage of the lesion, the skin is dark red or pink, and the hyperkeratotic site is white. In the late stage of the lesion, the skin is thickened, the pigment is increased, the skin texture is obvious, and mossy changes occur. The disease can coexist with vulvar invasive cancer.


Examination of vulvar squamous cell proliferation

1, secretion examination.

2. Perform local biopsy for pathological examination if necessary.


Diagnosis and differentiation of vulvar squamous cell hyperplasia


Diagnostic points

1, medical history

Have a temperament depression, or live in dampness, or take a lot of history, or a variety of vaginal inflammation and other medical history.

2, symptoms and signs

Middle-aged women who can occur at any age and are more common before the age of 50 can also occur in old age. The main symptoms are itching, how intense and difficult to tolerate. Itching is more severe due to the increasingly serious skin damage caused by repeated scratching. The range of lesions is different, mainly involving the labia majora, the interlabial space, the clitoris foreskin, the posterior labial joint, etc., often symmetry. When the early lesions are light, the skin color is blush or gray, and the hyperkeratotic site appears white. Due to long-term scratching and rubbing, the skin thickens like leather, the pigmentation increases, the skin texture becomes prominent, and the skin blemishes, which are mostly small polygonal flat papules, which are clustered into pieces and appear mossy. In severe cases, it may cause damage, cracks and ulcers of the epidermis. If the ulcer does not heal for a long time, especially when there is a nodular bulge, you should be alert to the possibility of local cancer. Generally no shrinkage or adhesion.

3, pathological biopsy

Pathological biopsy is the only means of diagnosis. Generally, it should be in 1% lidoca; for local anesthesia, multiple lesions such as erosion, ulcer, induration, and bulge are selected for multi-point biopsy.

Differential diagnosis

1, vitiligo: the disease caused by the destruction of melanocytes, no symptoms, can occur at any age, puberty is more common.

2, albinism: the epidermis basal layer contains only large and gray immature melanocytes, can not be caused by melanin, is a hereditary disease. Without the symptoms, the same lesion can be found in other parts of the body.

3, specific vulvitis: Candida albicans vulvitis, trichomoniasis vulvitis, diabetes vulvitis and other secretions and long-term stimulation of diabetes, can cause excessive keratinization of the vulvar epidermis, shedding and white. Candida albicans vulvitis, trichomoniasis vulvitis have increased secretions, itching, secretion examination can detect pathogens; if the vulva skin is symmetrical red, thick, accompanied by severe itching, but vaginal secretions are not many, may be Diabetic vulvitis. Specific vulvitis After the primary disease is cured, the white area disappears.