High alanine aminotransferase



High alanine aminotransferase (GPT, ALT) is a common phenomenon in the clinic. The liver is the body's largest detoxification organ. Whether the organ is normal or not is very important to the human body. GPT raises an important indicator of liver function problems. Among the common factors, various types of hepatitis can cause an increase in GPT, which is caused by damage to the liver. Some drugs, such as anti-tumor drugs and anti-tuberculosis drugs, can cause liver damage. Drinking plenty of food and eating certain foods can also cause liver damage for a short period of time.



There are many reasons for high alanine aminotransferase, such as acute hepatitis, taking drugs (especially drugs that are harmful to the liver), long-term drinking or drinking large doses at one time, and heart failure in certain biliary diseases and heart disease. , fever and other diseases can cause high alanine aminotransferase.

1, viral hepatitis This is the most common cause of elevated alanine aminotransferase ALT, all kinds of acute and chronic viral hepatitis can lead to high alanine aminotransferase ALT.

2, toxic hepatitis A variety of drugs and chemicals can cause alanine aminotransferase ALT increased, but after stopping the drug, alanine aminotransferase ALT can be restored to normal.

3. Increased alanine aminotransferase ALT in large or long-term drinkers.

4, liver cirrhosis and liver cirrhosis of liver cancer, generally there will be elevated alanine aminotransferase ALT, should be actively treated.

5, biliary tract disease cholecystitis, cholelithiasis acute attack, often fever, abdominal pain, nausea, vomiting, jaundice, blood bilirubin and alanine aminotransferase ALT increased.

6, heart disease acute myocardial infarction, myocarditis, heart failure, can increase alanine aminotransferase and aspartate aminotransferase, patients often have chest pain, palpitations, shortness of breath, edema. Cardiac examination has positive signs and abnormal ECG.

Alanine aminotransferase is mainly present in liver cells. When liver cells are damaged, alanine aminotransferase is released into the blood, so blood tests for liver function tests will find that alanine aminotransferase is high. Therefore, the general reason for the high alanine aminotransferase may be related to liver disease. Such as acute hepatitis B, cirrhosis, liver cancer and so on.

A mild elevation of alanine aminotransferase may be due to acute hepatitis, while a moderate increase in alanine aminotransferase is common in chronic hepatitis, such as chronic hepatitis B. The reason for the elevated transaminase in hepatitis B patients is caused by the chronic system attacking hepatitis B virus.

Hepatitis B virus is hidden in the liver cells, and the immune system attacks the hepatitis B virus to attack the liver cells, thereby causing damage to the liver cells and elevation of alanine aminotransferase. Hepatitis B virus transaminase is caused by hepatitis B virus. Therefore, hepatitis B patients with high alanine aminotransferase should be actively treated with hepatitis B antiviral therapy.


an examination

Related inspection

Liver function test liver ultrasound examination of hepatitis B two-and-a-half blood test

Symptoms: Insomnia, dreams, fatigue, anorexia, low fever, greasy, jaundice, nausea, vomiting, abdominal pain, diarrhea, liver discomfort, etc. Mildly expressed as easy to sweat, drowsiness, thirst, easy to fatigue when reading books.

Laboratory inspection:

1, blood test liver function, hepatitis B five items.

2, for liver color Doppler ultrasound to rule out lesions.


Differential diagnosis

There are many reasons for the increase in alanine aminotransferase, which should be identified.

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